2-3 days: If there is no improvement if 72 hours, you amy have a strain that is resistant to azithromycin. Rates of resistance to z pack are at least 40% here in the new york area. Let your doctor know if you still have severe pain or fever after 3-4 days. Keepin mind that the vast amount of tonsil infections are viral and will clear on their own in 7-10 days.
Answered 5/21/2016
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