A member asked:

My moderately elevated ast & alt improve on prednisone. i have uctd &celiacs. also take plaquenil (hydroxychloroquine) . im negative for ai hepatitis. what does this mean?

3 doctors weighed in across 2 answers

From celiac disease: Alt, ast maybe elevated in celiac disease plaquenil tends to help the liver? If the alkaline phosphatase and GGT are normal, ast, alt may come from other tissues.

Answered 9/24/2016

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Dr. Ashu Syal answered

Elevated liver enzym: Elevated liver enzymes indicate some kind of inflammation in liver. It does not have to be auto immune in origin. Many medications are known to cause elevated liver enzymes. Plaquenil (hydroxychloroquine) ( for instance) is notorious for causing this side effect even in therapeutic doses.

Answered 5/6/2019

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