Can an over sized running shoe be the cause of my foot pain?

Oversized shoe: It certainly can be since in an oversized shoe, your foot will piston back and forth inside the shoe and this can cause trauma to the foot.

Yes: If shoes are too large you feet will slide around in them and you will not be receiving proper support in the needed areas.

Possible: Make sure the shoes are not too small and not too large.

Possibly: There are many factors that may be in play that cause foot pain when running , inappropriately sized shoe wear maybe one of them. Have your foot measure to start width as well as length. New balance running shoes come in widths for instance. If resizing your shoes and backing off on the distance you run does not help see a ortho doc or podiatrist.