I have been taking 225mg of venlafaxine and 50mg of trazodone for a few months now. the doctor has added 150mg of bupropion a week ago. my friends say that i'm extremely moody and irritable and thinking more negatively.could the new medicines cause this?

Antidepressants: My concern is that u r on 3 antidepressants. Adding wellbutrin (bupropion) seems to coincide with the symptoms that developed. Discuss with the prescribing physician as soon as possible.

Yes: It's very important to communicate any changes like this to your physician, which i hope is a psychiatrist since you're on multiple psychopharmacological agents. Did the moodiness & irritablity develop after the wellbutrin (bupropion) was added? Are you sleeping? Do you, yourself notice a change? The wellbutrin (bupropion) could be very activating for you. Please see your doctor and see what s/he recommends.

BAD?: Very long time ago , i saw a patient who was on two benzodiazepine , three antidepressant and ritalin (methylphenidate). He was give given the diagnoses of {depression and adhd]....He continued to be irritable , depressed and angry . When i evaluated him i diagnosed him bad, i discontinued all psych med. And put him on lithium;upon follow up, he told me:" my wife will come to thank you, i never felt better...

3 antidepressants: Discontinuing the meds. Is a wise approach but has to be done gradually and closely monitored.