Is low blood sugar genetic?

Sometimes.: This is often a complication of diabetes therapy, and blood glucose management, but certain tumors, like insulinomas, among others, can cause this, and many of those patients have a family history of those tumors. Some others also have naturally low blood sugar, and that can be due to genetics. Congenital hyperinsulinism might be such a case, as might inborn errors of carbohydrate metabolism.