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A 39-year-old member asked:

is it problematic to take benadryl (diphenhydramine) every night to fall asleep?

1 doctor answer3 doctors weighed in
Dr. James Ferguson
Pediatrics 46 years experience
Rather benign med: Benedryl is the main sleep ingredient in most otc sleep products & as an otc med it has been show to be relatively safe, even when taken over a long term. That said, you may want to meet with your pcp, have a regular checkup & discuss any other symptoms that could point to a treatable condition that is interfering with natural sleep.

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Similar questions

CA
A 35-year-old member asked:

How quickly does Benadryl (diphenhydramine) start to work?

2 doctor answers3 doctors weighed in
Dr. Giana Nicoara
Allergy and Immunology 28 years experience
About 30 minutes: Lasts in the body for about 4-6 hours and then it needs to be redosed.
CA
A 36-year-old member asked:

How much Benadryl (diphenhydramine) is considered too much?

2 doctor answers4 doctors weighed in
Dr. Steven Machtinger
Allergy and Immunology 44 years experience
1 mg per 2 pounds: For children the correct dose is 1 mg/kg ( a kilogram is 2.2 pounds) every six hours as needed. Adults usually take 25-50 mg per dose. If you or your child need more than that you should consult your physician for advice. There are other drugs that are equally effective but cause less or no sedation and have fewer side-effects than Diphenhydramine (benadryl).
A 31-year-old member asked:

Are there long-term consequences to taking Benadryl (diphenhydramine) regularly?

2 doctor answers4 doctors weighed in
Dr. Steven Machtinger
Allergy and Immunology 44 years experience
No: When taken at recommended doses there are no cumulative adverse effects from the long-term use of Diphenhydramine (benadryl) or any other commonly used antihistamine.
A 44-year-old member asked:

Is it okay to mix Benadryl (diphenhydramine) with my other medications?

2 doctor answers2 doctors weighed in
Dr. Steven Machtinger
Allergy and Immunology 44 years experience
Avoid these: Older antihistamines like Benadryl (diphenhydramine) interact with many drugs. Don't mix it with alcohol, sleeping pills, sedatives, antidepressants, potassium supplements, sodium or potassium phosphate, antipsychotics, MAO inhibitors, symlin (pramlintide), sodium oxybate, Precedex (dexmedetomidine) & abilify (aripiprazole). Loratidine and fexofenadine are as effective & much safer. Discuss this with your doctor.
CA
A 33-year-old member asked:

Is frequent Benadryl (diphenhydramine) usage dangerous?

2 doctor answers4 doctors weighed in
Dr. Michael P Vaughn
Allergy and Immunology 34 years experience
No: There is a common misconception that frequent use of antihistamines leads to tolerance and eventual lack of effectiveness. This is untrue. Frequent use of decongestants that can lead to tachyphylaxis (lack of effect after several consecututive days of use) but there is no real justification for changing back and forth from Allegra to Claritin (loratadine) or to zyrtec. Typically if one works poorly, all will.

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Last updated Dec 9, 2019
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