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A female asked:

i took 5mg of valium 6 hours ago... is it safe to take 30 ml of diphenhydramine now to fall asleep? or will the two interact?

2 doctor answers6 doctors weighed in
Dr. John Chiu
Allergy and Immunology 57 years experience
Likely: ok but may add to the drowsiness which is apparently what you want.
Dr. Al Hegab
Dr. Al Hegabanswered
Allergy and Immunology 40 years experience
Will interact: taking both might increase CNS depression, better avoid, and exercise caution with multiple drugs, good luck

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A 38-year-old member asked:

What is the difference between first and second-generation antihistamines?

3 doctor answers5 doctors weighed in
Dr. Stephen Kimura
Allergy and Immunology 35 years experience
Side effects: The second generation antihistamines were developed to try and decrease the side effects of the first generations. Many are "purified" first generation antihistamines so they have the active effects without the side effects of drowsiness, sedation, dry mouth etc. They also tend to have longer half lives, meaning they can be taken once or twice a day not every 4 hours.
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A 39-year-old member asked:

Are there any prescription antihistamines?

2 doctor answers12 doctors weighed in
Dr. Alex Martinez
Specializes in Allergy
A few: Antihistamines have been around for many years & many that used to be prescription are now available over-the-counter. A few antihistamines are still prescription, including some first-generation (sedating) medicines like periactin or palgic as well as second-generation (less-sedating) medicines like xyzal (levocetirizine) and clarinex.
Dr. Maziar Rezvani
Allergy and Immunology 21 years experience
Hydroxyzine is still prescription as well
Nov 23, 2011
Dr. Paul Carter
A Verified Doctor commented
A US doctor answered Learn more
Many prescription medications have antihistamine properties. Talk to your personal physician about which medications are right for you.
Jan 1, 2012
A 27-year-old member asked:

Why is it that Benadryl (diphenhydramine) gives me a hangover?

2 doctor answers4 doctors weighed in
Dr. Stephen Kimura
Allergy and Immunology 35 years experience
Crosses into brain: There is a blood:brain barrier and medications can cross through this barrier to cause people to feel "hungover". People complain of feeling drowsy or paradoxically some people get insomnia. Non-sedating antihistamines (fexofenadine, loratidine, cetirizine) have less of this "crossover" and so cause less problems for people.
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A 27-year-old member asked:

Can Valium help calm alzheimer's patients?

3 doctor answers5 doctors weighed in
Dr. Joseph Roosth
Internal Medicine 35 years experience
Poorly: Valium, ativan, Xanax (alprazolam) and similar drugs calm the brain, but unfortunately act a little like giving liquor. They will work, but in alzheimer's patients are often associated with unwelcome side effects. It is important to always, first look for more simply treatable issues, like discomfort, hunger, senory impairment that may be treated with simpler solutions.
A 41-year-old member asked:

What does "valium 5mg IV q2h prn agitation" mean?

1 doctor answer3 doctors weighed in
Dr. Pamela Pappas
Psychiatry 42 years experience
IV Valium: Valium is a benzodiazepine medicine which can calm anxiety and agitation. "iv" denotes giving it intravenously -- i assume this patient is in the hospital or other medical unit. In this case, the person may be given 5mg of valium IV every 2 hours if agitated -- but the "prn" means it's only used "as needed" rather than around the clock.

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Last updated May 1, 2016
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