Yes but rare: Penicillin is mostly metabolized/breakdown by the liver and the by-product is then excreted to the outside world via the kidneys in the urine. Typically this does not affect kidney functions, but in the rare cases when penicillin causes interstitial nephritis, renal function is affected. So, if you are not taking any else and now has kidney trouble with penicillin, get it checked. Good luck.
Answered 7/9/2019
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