Can prozac (fluoxetine) make physical pain worse?

Prozac (fluoxetine): Not uncommon initial reaction to Prozac (fluoxetine) due to elevation in serotonin levels, subsides with time.

Prozac: Possibly - potential side effects could include migraine headache, mild headache, neuralgia, hyperesthesia, abdominal pain, breast pain, pelvic pain, chest pain, etc, etc. REF: https://www.drugs.com/sfx/fluoxetine-side-effects.html. Hopefully if you have any side effects they will be transient.