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A 47-year-old male asked:

I had uveitis hla b27 disorder. it flares up once in a year. i have no specific symptoms of rheumatic arthrits. how to rule out sle and auto immune ?

3 doctor answers10 doctors weighed in
Dr. John Goldman
Rheumatology 56 years experience
Not SLE: Hla b 27 is not associated with stomach lupus erythematosus. It is found in four to eight percent of the normal caucasian population. It is associated with ankylosing spondylitis a spondyloarthropathy. As you know it can also be associated with uveitis, but not with systemic lupus erythematosus or similar autoimmune diseases.
Dr. Ilan Cohen
Ophthalmology 26 years experience
See a rheumatologist: A variety of blood tests can be performed along with a detailed history and physical examination to look for conditions associated with uveitis. A rheumatologist is the most qualified to perform this work up.
Dr. Richard Bensinger
Ophthalmology 53 years experience
Anklyosing spondy: There is a high likelihood that you have ankylosing spondylitis which correlates with the hlab27 already shown to exist in your immune picture. Uveitis is an accompaniment of this condition and can be quite severe. You should check with a rheumatologist as there are features of anklyosing which should be treated to prevent permanent change.
Dr. Ed Friedlander
Pathology 45 years experience
HLA-B27 uveitis is unrelated to lupus, and the diseases to which it is related are most dangerous if they affect the ring of the aortic valve of the heart, which is uncommon. However, they are major nuisances. Your rheumatologist -- who you should consult -- may know when the time is right to administer a biotech immunomodulated.
Aug 29, 2012

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