The difference between ibuprofen and aspirin?

See below: Aspirin is a nonsteroidal anti-inflammatory drug (nsaids), but differs from most other nsaids in the mechanism of action. Though it, and others in its group called the salicylates, have similar effects (antipyretic, anti-inflammatory, analgesic) to the other nsaids and inhibit the same enzyme cyclooxygenase, Aspirin (but not the other salicylates) does so in an irreversible manner.

Both are NSAIDs. But: Asa has a 14 day effect on platelet coaguability. Ibuprofen has this effect only as long as it is in the blood stream. Asa has an effect caused by de-acetylation, on thromboxane synthesis by the lining of blood vessels , which inhibits atherosclerosis. This effect does not occur with nsaids other than asa, which may slightly increase it's risk. All may decrease arthritis pain, but asa is unique.