I have a 22month old girl an she start 3 days ago with fever( 40.1) her pediatrician gave her antibiotics and advil (ibuprofen) but high fever persist.?

Fever is OK: It is ok for your child to have the fever as long as you are able to reduce it with either advil or tylenol (acetaminophen). Keep in mind that fever is a sign of healthy response to infection. It is considered a self defense mechanism. If the fever persist and it is higher than 104, it can be dangerous and you would need to take your kid to an er. As for antibiotics, it takes about 2 days to kick in. Call her md.

Call your doctor: Typically bacterial infections improve within 48-72 hours of starting to take an antibiotic. If your baby is not improving, either the infection is viral (and no antibiotic will be either necessary or helpful), or your baby may need a stronger antibiotic in order to cure the infection. Either way, another exam at this point sounds necessary to determine the most appropriate way to proceed.

Call Doctor: I'd suggest you discuss with your doctor. Perhaps another exam, additional tests, or a different antibiotic will be needed. Since she hasn't shown improvement yet, your doctor needs to know.