How is an enlarged spleen different from a fatty liver?

Different organs: A fatty liver is a condition where excess fat cells build up in the liver and can negatively affect the function of the liver. In bad cases it can sometimes cause a type of cirrhosis. An enlarged spleen can be caused by significant liver damage from a variety of causes, or an enlarged spleen can be caused purely from spleen or blood disorders.

Different organs: Spleen is on upper left side of abdomen and filters blood of bacteria and dead cells. Liver is upper right and metabolizes substances, makes proteins, controls acid-base among others. If fatty liver progresses to cirrhosis -scarred liver- the blood pressure in the liver vessels can get high. This can back up into the spleen and cause it to get congested and enlarged.