A member asked:

Can being obese cause an enlarged spleen? i was severely overweight, have fatty liver, but lft's are normal. so the liver seems to be functioning fine, wondering what could cause the spleen issue?

2 doctors weighed in across 2 answers

Yes: Non alcoholic fatty liver can cause portal hypertension which is a cause of spleen enlargement. Portal hypertension means that there is increased pressure and abnormal blood flow in portal vein system. Portal vein brings blood to the liver.

Answered 6/29/2016

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Dr. Raad Jajo answered

Many explanations: one most possible cause is portal hypertension, others could hypersplenism due to overdestructions of RBC

Answered 5/14/2019

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