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A 36-year-old female asked:

can being obese cause an enlarged spleen? i was severely overweight, have fatty liver, but lft's are normal. so the liver seems to be functioning fine, wondering what could cause the spleen issue?

2 doctor answers2 doctors weighed in
Dr. Tamara Modilevsky
Internal Medicine 54 years experience
Yes: Non alcoholic fatty liver can cause portal hypertension which is a cause of spleen enlargement. Portal hypertension means that there is increased pressure and abnormal blood flow in portal vein system. Portal vein brings blood to the liver.
Dr. Raad Jajo
Psychiatry 23 years experience
Many explanations: one most possible cause is portal hypertension, others could hypersplenism due to overdestructions of RBC

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Last updated May 14, 2019

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