What are the side effects of progesterone?

GERD/vaginal dischar: Vaginal Progesterone (prochieve or crinone) is a very safe and effective intervention to prevent preterm birth in women with asymptomatic short cervix! topical irritation or discharge can occur but are rarely a cause to stop the therapy. If you have gerd (reflux) or constipation the extra Progesterone will make them worse. Talk to your obstetrician to determine if this is a good idea for you.