A member asked:

Can zolft cause aggitation with people with bipolar diorder?

12 doctors weighed in across 4 answers
Dr. Rudolf Brutoco answered

Specializes in Child Psychiatry

It is possible.: Zoloft (sertraline) can be very effective in a variety of mood disorders (including sometimes as 1 rx in a med regimen treating someone w/ bipolar tendencies)& anxiety conditions. But it must be carefully rx'd, used & monitored because any ssri can incite/amplify mania. In other words, it can make the bipolar worse.It's a fine line to use psychoactive meds effectively, & requires expert md plus close follow-up.

Answered 5/5/2016

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Dr. Alan Ali answered

Specializes in Psychiatry

Zoloft (sertraline): General rule is to stabilize moods with mood stabilizers/antipsychotics before cautiously starting or adjusting the antidepressants. Some antidepressants are less likely to induce mania than others.

Answered 10/3/2016

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Zoloft (sertraline): In some cases, an ssri used alone, in a person who is bipolar, may cause rapid cycling.

Answered 5/14/2016

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Yes: Antidepressants, also known as mood elevators can elevate a person's mood. If a person has bipolar d/o- antidepressants like zoloft (sertraline) can cause a person to 'cycle' into a manic or hypomanic episodes. This is why some studies show that certain folks with bipolar d/o do best in the long run by staying off antidepressants, or only using them on a temporary basis. Also, too high a dose can agitate.

Answered 12/24/2012

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