Can muscular dystrophy be isolated to one single muscle?

No.: Muscular dystrophy is a group of inherited diseases which cause progressive weakness of muscles that allow movement. Muscular dystrophy usually will affect every muscle in a person with the disease. Symptoms may be more noticeable at first in one muscle but will progress. In one type of muscular dystrophy, the symptoms predominately affect muscles in the shoulder and pelvic girdles.