Will it help prevent any nausea if i eat before taking a antidepressant like zoloft (sertraline)?

It might: Gi side effects of medication are often less if the medications are taken with or after food. Often, side effects like nausea are very transient and, after a week or two, may no longer bother you, once you get accustomed to the medication. If you continue to have severe nausea, vomiting, diarrhea, or loss of appetite, speak to your doctor about a change of medication.

Yes Eating Can Help: Nausea is a common side effect with many medications, including zoloft (generic sertraline). By eating before you take your medication you effectively buffer the medication in your gastrointestinal system. Buffering refers to something that lessens the impact in this case the side effect of nausea. With zoloft one is encouraged to take it with food as food helps absorb the medication better.