Muscle or heart : CPK can be released from damaged or inflamed muscles, including the heart muscle. Some muscle diseases that cause weakness and pain in the muscles can elevate cpk, as can any muscle injury (including an injection into the muscle). Heart attacks and other heart muscle injury or inflammation can also raise the cpk. There are tests to determine the source of the cpk. ("fractionation" of cpk).
Answered 5/9/2018
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Muscle injury: Injury to skeletal muscle is a common cause. Visit this site for more info: https://medlineplus.gov/ency/article/003503.htm
Answered 4/5/2019
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