Can anyone have hereditary angioedema?

Yes: Hereditary angioedema types 1 and 2 have a very strong genetic component and typically runs in families. However, spontaneous mutations can occur and hae i and ii can occur on anyone.

Yes: 75% of HAE pts have the disease based on genetics (autosomal dominant). 25% have a spontaneous mutation. 50% of pts will have an attack by age 10 years and and then a larger proportion of pts during puberty. Type I (85% of pts) is based on low levels and low function of C1 inhibitor. Type II involves normal or elevated C1 inhib levels but low function. Both look exactly alike clinically.