A member asked:

Is it ok to smoke marijuana for pain relief if i am on warfin?

15 doctors weighed in across 7 answers
Dr. Seth Zeidman answered

Specializes in Neurosurgery

No: Marijuana may increase warfarin anticoagulant effect by inhibiting its metabolism, and to a lesser extent, displacing warfarin from protein-binding sites.

Answered 3/28/2019

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Dr. Jeffrey Clemens answered

Specializes in General Surgery

Probably: I was able to find one interaction report that marijuana may increase the INR, but that shouldn't be an issue if you have the INR checked regularly. No other significant interactions on a literature search.

Answered 4/1/2019

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No: Marijuana may block the metabolism of the warfarin. This will mean you will be excessively anti-coagulated..

Answered 4/1/2019

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Dr. Reza Emami answered

Specializes in Family Medicine

Probably not: There maybe a risk of increasing the INR, you should follow up with your primary care provider, I hope this helps.

Answered 3/28/2019

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No: Not only could there be potentiation of warfarin effect, MJ is a psychoactive drug and will mess with your brain. Talk to the doctor who prescribed warfarin and seek her/his advice about pain relief.

Answered 3/29/2019

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Dr. Seth Zeidman answered

Specializes in Neurosurgery

No: Marijuana may increase warfarin anticoagulant effect by inhibiting its metabolism, and to a lesser extent, displacing warfarin from protein-binding sites.

Answered 3/10/2019

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Alternative thinking: The warfarin is on board to thin your blood. The marijuana likely will neither increase nor decrease your bleeding risk, though it can affect your blood pressure. Acetaminophen is similar but has liver toxicities. The NSAIDS and aspirin increase your bleeding risk. Just avoid MJ with Tramadol - it is a bad combination.

Answered 3/12/2019

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