A member asked:

How is alzheimer's inherited?

4 doctors weighed in across 3 answers
Dr. Maureen Nash answered

Specializes in Geriatric Psychiatry

Depends: Early onset illness is inherited at a high rate but the more common late onset alzheimers has a number of genes taht increase risk a small amount each.

Answered 8/2/2012

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Autosomal Dom: In 2-5 % of cases there is a familial autosomal dominant pattern, associated with three more common mutations. Amyoid precursor protein, presenilin i, and presenilin ii. The disease presents often in the 30's and 40's in these groupsl.

Answered 9/28/2016

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Dr. Jeffrey Satinover answered

Specializes in Psychiatry

Not yet known: Many details about the genetics of ad are known as colleagues indicate, it remains an area of research and competing hypotheses (see http://www.Alzheimersblog.Org/tag/genetic/?Gclid=clddgfsv5lucfy07ogodkhmazw). Like most human conditions many genes appear to influence ad. This yields a "risk" model, where certain conditions elevate the likelihood of offspring having ad without guaranteeing it.

Answered 12/10/2013

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