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A 37-year-old member asked:

Do you and your partner have to carry the same mutation to have a child with cf ?

2 doctor answers6 doctors weighed in
Dr. Gurmukh Singh
Pathology 49 years experience
Not exactly: The mother and father can have different abnormalities in the gene. If the baby inherits two defective copies of the gene s/he is likely to get cf, even though the abnormalities are not exactly the same in parents.
Dr. James Ferguson
Pediatrics 46 years experience
80% Delta 509: I believe there are at least 2 dozen variations of the CF gene that can pair up to produce the disorder.Most kids will have 2 of the delta 509 variation, but one of these along with another variant will still produce CF. This is responsible for some of the variation in presentation and symptom expression at different ages.

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A 39-year-old member asked:

Could you and your partner have to carry the same mutation of cf?

1 doctor answer1 doctor weighed in
Dr. James Ferguson
Pediatrics 46 years experience
Confusing question: There are tests to define the mutation carried by asymptomatic CF carriers.The majority carry the same mutation, delta f508, but there are many others. The variation on different possible pairings is felt responsible for differing expression of CF patterns.

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Last updated Oct 30, 2015
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