A member asked:

Is ti true that fibromyalgia or depression cause a change in leptin levels?

3 doctors weighed in across 2 answers
Dr. Vasu Brown answered

Specializes in Integrative Medicine

Connected yes: The metabolic effects of leptin resistance include a diminished TSH secretion, a suppressed T4 to T3 (liothyronine) conversion, an increase in reverse t3, (liothyronine) an increase in appetite, an increase in Insulin resistance and an inhibition of lipolysis (fat breakdown). These effects of leptin resistance on thyroid hormones contribute to the drop in TSH and T3 (liothyronine) levels - and cause thyroid induced myopathy(fibro) depression.

Answered 1/15/2015

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Not with fibromyalgi: No association with fibromyalgia but somatic depression can independently alter leptin levels.

Answered 4/4/2013

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