No: Omeprazole (prilosec) is not known to cause high cholesterol. Long term use may lower absorption of calcium, vitamin b12, etc... Older folks may have a higher risk of hip fractures. Stomach acid kills germs, so some infections may be more likely in a person with suppressed acid. If a person's diet stayed the same, but his cholesterol increased after starting omeprazole, his doctor can investigate.
Answered 11/16/2017
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