HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

How soon does zoloft (sertraline) start working?

A doctor has provided 1 answer

Typically, 3-6 weeks: Zoloft (generic name sertraline) is an antidepressant/antianxiety medication in the family known as selective serotonin reuptake inhibitors (ssri's). Like most of these medications, the effects are not seen immediately. For most patients, these medications take 3-4 weeks to start to work.

Dr Ali and 2 doctors agreed

Answered 3/1/2016

5.7k views

Thank

Related Questions

A member asked:

What is the equivelant dosage of for 100mg of Zoloft (sertraline) . My doctor is thinking of changing me from Zoloft (sertraline) because it doesn't seem to be working?

6 doctors weighed in across 3 answers

A member asked:

Zoloft (sertraline) is not working, any ideas on what my dr. Might do?

A doctor has provided 1 answer

A member asked:

My pdoc increased my Zoloft (sertraline) from 50mg daily to 100. Will i get side effects and how long to feel the effects of it working?

A doctor has provided 1 answer

A member asked:

I took Zoloft (sertraline) for 15years it stopped working I take 20mgescitalopram for 6 months still having anxiety would it be safe to go back to zoloft (sertraline)?

A doctor has provided 1 answer

A member asked:

What could relieve or lower anxiety when working with others? Zoloft (sertraline) 50mg Metformin 500mg

2 doctors weighed in across 2 answers

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

I am coming off Zoloft, (sertraline) it worked for me last time, saved me. this time a year or two later it isn't working. did I build up a tolerance?
Will i really be able to tell the difference when the Zoloft (sertraline) starts working?
How to know that Zoloft (sertraline) not working to me . im taking it over 4 months. Thank you?
I've been taking Zoloft (sertraline) for 12 years. It has stopped working. Is there a better substitue?
Could Zoloft (sertraline) stop working?

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.