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A 52-year-old female asked:

do histamines (not antihistamine medications) make you drowsy? antihistamines (no decongestants added) seem to make me more alert when allergies flare

1 doctor answer3 doctors weighed in
Dr. Jeffrey Rumbyrt
Allergy and Immunology 32 years experience
Yes: Histamine is a substance released during an allergic attack and can cause drowsiness. Some of the older generation anti-histamine agents (like benedryl) can cause drowsiness because they can pass the "blood brain" barrier and cause a direct effect on thinking. In rare cases in adults, antihistamines can cause agitation.

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Last updated Jul 2, 2018
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