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A member asked:
Do histamines (not antihistamine medications) make you drowsy? antihistamines (no decongestants added) seem to make me more alert when allergies flare
A doctor has provided 1 answer
Yes: Histamine is a substance released during an allergic attack and can cause drowsiness. Some of the older generation anti-histamine agents (like benedryl) can cause drowsiness because they can pass the "blood brain" barrier and cause a direct effect on thinking. In rare cases in adults, antihistamines can cause agitation.
Answered 7/2/2018
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