A member asked:

Do histamines (not antihistamine medications) make you drowsy? antihistamines (no decongestants added) seem to make me more alert when allergies flare

A doctor has provided 1 answer

Yes: Histamine is a substance released during an allergic attack and can cause drowsiness. Some of the older generation anti-histamine agents (like benedryl) can cause drowsiness because they can pass the "blood brain" barrier and cause a direct effect on thinking. In rare cases in adults, antihistamines can cause agitation.

Answered 7/2/2018

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