How long does it take for morphine to wear off?

Depends..: Oral morphine is short acting form or immediate release form has a half-life of 2-3 hours and will be at levels of 50% by that time. The long acting form of morphine can last 8-12 hours (i.e. Kadian, embeda, Morphine Sulfate sustained release - mssr).

Depends on Type: It all depends on the type of morphine one is taking. There is an immediate release form (ir) and several extended release (er) forms (ms contin, kaidan, avinza, morphine cr). You can expect most ir formulation to last 4-6 hours. Depending on the patient's metabolism some last a little less or more. The er forms last any where from 12 -24 hours depending on the brand.

Pharm: Depending on the formulation of the morphine and your inherent metabolism, it can take anywhere from a few hours to a day for the analgesic effects of morphine to wear off.