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A 36-year-old member asked:

How long does it take for morphine to wear off?

3 doctor answers6 doctors weighed in
Dr. Aj Rastogi
Pain Management 18 years experience
Depends..: Oral morphine is short acting form or immediate release form has a half-life of 2-3 hours and will be at levels of 50% by that time. The long acting form of morphine can last 8-12 hours (i.e. Kadian, embeda, Morphine Sulfate sustained release - mssr).
Dr. William Newton
Pain Management 19 years experience
Depends on Type: It all depends on the type of morphine one is taking. There is an immediate release form (ir) and several extended release (er) forms (ms contin, kaidan, avinza, morphine cr). You can expect most ir formulation to last 4-6 hours. Depending on the patient's metabolism some last a little less or more. The er forms last any where from 12 -24 hours depending on the brand.
Dr. Bahman Omrani
Pain Management 17 years experience
Pharm: Depending on the formulation of the morphine and your inherent metabolism, it can take anywhere from a few hours to a day for the analgesic effects of morphine to wear off.

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Aurora, CO
A 47-year-old male asked:

How long does it take for morphine et start to work?

2 doctor answers2 doctors weighed in
Dr. Mohammed Parvez
Internal Medicine 14 years experience
Morphine: Depends on what type of morphine. The injectable form start acting in few minutes. The immediate acting tablets may take 15 minutes and sustained release tablets may take upto 1 hour.

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Last updated Sep 12, 2018

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