Genetic or not: Brittle bone disease is an inherited disorder of bone that is called osteogenesis imperfecta. Osteopenia and osteoporosis are disease of the bone where there is decrease density of the bone. This is associated with age, hormonal change, medications, smoking and other issues. Basically the bone cells are out of balance and take away more bone than they replace.
Answered 6/22/2020
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A matter of degree: Osteoporosis is just severe osteopenia (not enough bone mineral). Osteogenesis imperfecta is the prototypic brittle bone disease. This disease is a disorder of the protein in bone. Bone is made up of proteins and minerals.
Answered 9/1/2012
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