What could lead to low platelets and painful joints?

Rheumatoid arthritis: Rheumatoid arthritis lupus itp and other autoimmune diseases can cause joint pain and low platelet count.

Varies: There are a number of possibilities, some very benign and others much more serious. A detailed exam and further studies can usually determine the cause. Among some of the potential causes include an inflammatory arthritic condition, a malignancy, or a reactive arthritis associated with a thrombocytopenia. You certainly would need thorough evaluation. Thank you for the question.