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A 38-year-old member asked:

What's the difference between pernicious anemia and b12 anemia?

1 doctor answer2 doctors weighed in
Dr. Ralph Morgan Lewis
Family Medicine 39 years experience
See below: B-12 anemia is a deficiency in vitamin b-12 (cobalamin). Pernicious anemia is a deficiency or lack in intrinsic factor (produced by cells in the stomach) which is a protein essential for absorption of vitamin B12 in the ileum (small intestine). Pernicious anemia requires replacement of intrinsic factor &/or b-12. B-12 anemia needs only b-12 supplementation.

Similar questions

A 44-year-old female asked about a 63-year-old female:

Does pernicious anemia cause high serum b12?

1 doctor answer1 doctor weighed in
Dr. Vance Harris
Family Medicine 38 years experience
Low vitamin B12.: pernicious anemia is a LOW vitamin B12 state. This occurs when the body fails to make enough of a specific protein to enable the body to absorb vitamin B12. This usually occurs when the immune system attacks a specific cell in the stomach that produces the needed protein. Since the body can't absorb vitamin B12 through the stomach it can be given in a shot and even under the tongue.
A 42-year-old member asked:

I was wondering is B12 deficiency the same as pernicious anemia?

1 doctor answer3 doctors weighed in
Dr. Lauren Stegman
Radiation Oncology 28 years experience
Related: Technically, pernicious anemia (pa) is due to low B12 levels caused by changes in the stomach resulting in decreased ability to absorb the B12 from a lack of something called "intrinsic factor." there are other causes of B12 deficiency that technically are not pa. Today, tests can find B12 deficiency before someone has symptomatic anemia so deficiency by itself is not always pa.
Last updated Jun 24, 2014


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