What is the main difference between aderall and vyvanse (lisdexamfetamine)?

Very Similar: The body metabolizes vyvanse (lisdexamfetamine) into a chemical that is found in the medicine adderall, so they are very similar medications. The primary difference is that vyvanse (lisdexamfetamine) tends to take effect a little more gradually and will often give a longer duration of action from a single dose. In general, vyvanse (lisdexamfetamine) tends to tolerated a little better, although the posible side effects are the same.