Side-effect profile: Benadryl (diphenhydramine) is one of the first generation anti-histamines which cross the blood-brain barrier and therefore causes sedation. It also has a significant drying effect in many patients. Claritin (loratadine) is a second generation and does not cross into the brain and therefore is considered non-sedating. It is usually less drying as well.
Answered 11/28/2015
5.7k views
5 doctors weighed in across 2 answers
A doctor has provided 1 answer
A doctor has provided 1 answer
2 doctors weighed in across 2 answers
90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.
Ask your question