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A 46-year-old member asked:

Cani take benadryl (diphenhydramine) with loratadine?

1 doctor answer2 doctors weighed in
Dr. Donald Alves
Emergency Medicine 24 years experience
Probably yes.: Many people report their 'daily' non-sedating antihistamine in the am does not provide relief until next am. So, if no concerns for gu/heart/bp/med-conflict issues, then they often take a 'sedating' antihistamine at night for continued symptom relief and 'bonus' of sleep aid effect.

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A 37-year-old member asked:

Is loratadine like benadryl (diphenhydramine)?

1 doctor answer3 doctors weighed in
Dr. Donald Alves
Emergency Medicine 24 years experience
Kinda mostly: Loratadine is a 'non-sedating antihistamine, ' and Diphenhydramine (/benadryl) is a sedating antihistamine (aka: older / h1 & h2 blocker), so yes, they are close cousins in intended effects--just differ in side effects.
A 48-year-old member asked:

What is the difference between loratadine and benadryl (diphenhydramine)?

2 doctor answers3 doctors weighed in
Dr. Diane Minich
Family Medicine 37 years experience
Different antihistam: Both are antihistamines. Benadryl (diphenhydramine) is a sedating shorter acting antihistamine and Loratadine is a longer acting non sedating antihistamine.
A 33-year-old member asked:

Can i take diphenhydramine with loratadine?

1 doctor answer4 doctors weighed in
Dr. John Chiu
Allergy and Immunology 57 years experience
Yes: Antihistamine is safe even with 4x the average daily dose. The major side effects would be dry mouth and drowsiness ( the latter much less common if one uses the non-sedating type).
A 40-year-old member asked:

Can I take diphenhydramine and loratadine together?

2 doctor answers3 doctors weighed in
Dr. Mandakini Patel
Pediatrics 41 years experience
Benadryl/Claritin : If you have really bad allergies yes you can take them together. But you should see an allergy doc if you need to do this frequently.

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Last updated Mar 16, 2021
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