Do benadryl (diphenhydramine) and adderall interact with each other?

Drug interactions.: Benadryl (diphenhydramine) can be sedating (typically) or stimulating (unusual) . When a reaction occurs opposite to what is typically experienced, it is called a paradoxical reaction. A pharmacist can run a drug interaction screen for you and this is why it is wise to get all of your medications from a single source. Decongestants are stimulants and often used in combination with Benadryl (diphenhydramine) and could be a bad mix.

Not directly: No, they really do different things and have different mechanisms of actions. Each can make one's mouth very dry, so the combination can make one's mouth even dryer. Other antihistamines like Allegra (fexofenadine) (fexofenidine), cause less dry mouth.