A 39-year-old member asked:
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if you take adderall and benadryl (diphenhydramine) what happens?

1 doctor answer
Dr. Mitchell Cohen
36 years experience Psychiatry
No big risks: Adderall, a stimulant, and benadryl, (diphenhydramine) an antihistamine, have somewhat opposite effects. Adderall increases alerting brain chemicals like Dopamine while Benadryl (diphenhydramine) reduces the alerting chemical histamine. Adderall is alerting; Benadryl (diphenhydramine) is sedating. There are no drug-drug interactions between the 2 drugs. If both are indicated, they are safe to use together.
Answered on Aug 9, 2019
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