No big risks: Adderall, a stimulant, and benadryl, (diphenhydramine) an antihistamine, have somewhat opposite effects. Adderall increases alerting brain chemicals like Dopamine while Benadryl (diphenhydramine) reduces the alerting chemical histamine. Adderall is alerting; Benadryl (diphenhydramine) is sedating. There are no drug-drug interactions between the 2 drugs. If both are indicated, they are safe to use together.
Answered 8/9/2019
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