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A 32-year-old member asked:

What is the difference between a gluten allergy/sensitivity and celiac disease? are both hereditary?

1 doctor answer1 doctor weighed in
Dr. Gurmukh Singh
Pathology 49 years experience
Genetic component: Gluten sesitiviy and celiac disease are the same for all practical purposes. There is a hereditary component to the disease in that it requires the presence of hla dq 2 or 8 marker and these markers are inherited. Early exposure to gluten in infancy increases the risk of developing gluten sensitivity, so there is an enviornmenatal factor also in addition to genetic one.

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A 34-year-old member asked:

How do a gluten allergy/sensitivity and celiac disease differ?

1 doctor answer1 doctor weighed in
Dr. Martin Fried
General Practice 36 years experience
Autoimmune: Allergy is mediated by immunoglobulin e usually and doesnt damage the intestine wall. Celiac is a autoimmune disease where the antibodies attack the lining of the intestines and affect the absorption of food. Celiac can also lead to other autoimmune diseases.
A 40-year-old member asked:

Doctors, what is the difference between celiac disease and gluten allergy?

1 doctor answer1 doctor weighed in
Dr. Rajiv Arora
Allergy and Immunology 21 years experience
Sxs/mechanism: A true food allergy goes through the immune system and causes a sudden, potentially life threatening reaction (anaphylaxis) which includes hives, swelling, breathing sxs, GI sxs, heart sxs, nasal/eye sxs. This can be diagnosed by an allergist. Celiac is a different immune response to gluten in the gut. Symptoms can be more subtle (stomach sxs and others) and initial eval involves a blood test.
A 40-year-old member asked:

What are the causes of celiac disease (gluten allergy)?

2 doctor answers2 doctors weighed in
Dr. Robert Kwok
Pediatrics 33 years experience
A reaction to gluten: Celiac disease (gluten allergy) occurs in a person who may have a genetic tendency to react abnormally to gluten (a protein in wheat, barley, and rye). Something causes his immune system to over-react to gluten. Later, when he eats foods containing gluten, his immune system reacts with the intestine that is digesting the gluten, thus causing intestinal problems and abnormal digestion.

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Last updated May 9, 2019
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