What's the best anti-depressant today to help with low mood?

Varies: There is no single best antidepressant medication. Each person responds differently. In fact, on average, most antidepressants are about equally effective statistically. However, for a given person, medication.

Best antidepressant: There is no best antidepressant for all. Different antidepressants work differently in different people based on tolerability, side effects, other medications used concomitantly, metabolism, diagnosis, only to mention a few.