My boyfriend has huntington disease. his mood are very up and down could he be prescribed bi polar meds to help cause the anti depressant are not work?

Yes, an option: Huntington's is such a roller coaster ride in mood. I am assuming that depression is the major concern, but if several antidepressant therapies have been tried and maxed out, then mood stabilization meds may be tried in addition to antidepressants. Most mood stabilizers require close monitoring, so close follow up with a psychiatrist or neurologist may be necessary.

Maybe: If being "up" were consistent with an episode of mania, then consideration should be given to prescribing "bipolar meds" if being "up" is just no longer being depressed then they would not be appropriate.