A member asked:

Why does the skin appear to have a bronze color in individuals with adrenal insufficiency?

2 doctors weighed in across 2 answers
Dr. Cayce Jehaimi answered

Specializes in Pediatric Endocrinology

High ACTH: Increased skin pigmentation in individuals with ai is due to increased acth production which in turn activates the production of melanin by the pigment cells (called melanocytes) in the skin via melancyte stimulating hormone (msh). Keep in mind that hyperpigmentation is not noted in patients with secondary or central adrenal insufficiency due to lack of acth elevation.

Answered 11/18/2011

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Hormone: Hormone associated with this causes pigment cells to make more pigment.

Answered 3/25/2013

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