What role does the ldl receptor play in high cholesterol?

Familial hyperchol-: Estrolemia. Ldl receptor is a key component in the metalboism of LDL and defects in the receptor protein are associated with high LDL levels. There multiple types of inherited defects of the receptor and people with homozygous defective genes may have very high LDL and early onset of cardio-vascular disease.

Huge LDL Role: Low density lipoproteins, protein particles present 24/7 which transport all fats in the water outside cells, are the primary driver of atherosclerosis. Ldl receptors on cell membranes recognize LDL particles and pull them in so the cell can intake fat molecules. Ldl receptors on the liver cells play a huge role in keeping LDL concentrations down. Psck9 inhibitors are most powerful agents to date.