A 43-year-old member asked:
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what is meant by having estrogen receptor positive breast cancer?

3 doctor answers
Dr. Samir Gupta
28 years experience General Surgery
Hormone responsive: Er positive breast cancer means that the cancer expresses estrogen receptors. This is beneficial because we can hormonally manipulate this type of cancer with drugs like tamoxifen and Arimidex (anastrozole) which are antiestrogens.
Answered on Jan 12, 2016
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Dr. Jacqueline Matar
65 years experience Radiation Oncology
ER+: Estrogen receptors are small proteins found on the surface of some cancer cells. A positive result means the proteins are present, a negative result means they are not present.
Answered on Aug 8, 2013
6
6 thanks
Dr. Richard Orr
43 years experience Surgical Oncology
Feeds the cancer: Most breast cancers are estrogen receptor positive. The cancer cells have receptors that fit the estrogen molecule that a body produces. Think: a lock and key - when estrogen binds to the receptor the tumor cell is stimulated to grow and divide. Er+ tumors can be blocked by tamoxifen and Arimidex (anastrozole) (and others) that interfere with this pathway.
Answered on Nov 28, 2017
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Dr. Barry Rosen
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A 46-year-old member asked:
Dr. Regina Hampton
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Dr. Sean Canale
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Yes but: From a breast cancer standpoint, if the tumor is er negative, exogenous hormones don't have a target and won't have an impact. If the original tumor ... Read More
A 36-year-old member asked:
Dr. Liawaty Ho
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No: not indicated for estrogen receptor negative breast cancer.

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