A member asked:

Is there something called a k ras gene that causes lung cancer?

7 doctors weighed in across 2 answers

Yes: Kras is a gene involved in a pathway that controls cell growth. A mutationin the kras gene can lead to a propensity to develop lung cancer. There are several clinical trials that look at inhibitors in that pathway to treat patinets with advanced kras mutant lung cancer.

Answered 2/16/2015

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Dr. Liawaty Ho answered

Specializes in Hematology and Oncology

Yes: Mutation in the k-ras oncogene- which is the most common one found in lung cancer especially in adenocarcinoma- result in malignant transformation. Tumors with k-ras mutations tended to be smaller but more poorly differentiated, and they were associated with a significantly worse 3 year mortality rate .Attemps to overcome the impact of k-ras mutation in cancer is underway.

Answered 12/12/2013

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