Does hormone therapy for prostate cancer cause mental confusion?

Maybe: Long term therapy with testosterone blocking agents such as lhrh agonist drugs can cause significant fatigue. In patients with high degree of fatigue, mental confusion can be a side effect. Regular light exercise both physical and mental is helpful in many cases.

Generally - No: Hormone blockade (hb) can cause many problems but they tend to be time related. The longer on hb the more the problems. Hb often makes pre-existing problem worse or accelerates some problems. Hb itself rarely causes "confusion", more often it can cause depression, fatigue, and emotional changes. Only older men on hb for a very long time tend to have true cognitive dysfunction.