Burning hot pain on back of knee that spreads to calve with minor twitch. gets worst when lying down or at rest. no injury, swelling nor redness?

Neuropathy: seems like a nerve is being pressed upon which then sends out "messages" to u. This called neuropathic pain-the burning. The nerve may not necessarily be compressed at the knee, but can be at the hip or back. Ur primary care doc can start a work up and do a physical exam to see where it may be originating from, and refer u to a specialist if need be.