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A female asked:

Can benadryl (diphenhydramine) help a swelling and hive reaction (itching) allergic reaction to penicillin?

1 doctor answer1 doctor weighed in
Dr. Al Hegab
Dr. Al Hegabanswered
Allergy and Immunology 41 years experience
Depends: on the reaction, if just hives and itching, yes benadryl (diphenhydramine) can control it in the right dosage, after discontinuing the offending drug, but if more severe symptoms/swelling you need medical attention with the possible addition of epinephrine and probably steroids,
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Last updated Nov 23, 2019

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