Can you take reglan (metoclopramide) together with benadryl for migraine headaches?

Yes: May cause some over sedation, but some people have neurologic reactions to reglan (metoclopramide) that the benadryl may counteract. Not sure if would have a additive effect on migraine pain though.

Yes, you can: Benadryl may help blunt the tightness side effects of Reglan (metoclopramide). FYI, effective management of migraine involves three specific strategies: 1) patient education, 2) nonpharmacological management, and 3) pharmacological (medical) management. See an orofacial pain or headache specialist for evaluation and professional management.