Reglan and zofran sometimes gives me headaches, is it safe to take tylenol (acetaminophen) to relieve this? i take reglan routinely and zofran as needed.

Yes : Yes, no problem adding Tylenol (acetaminophen) to your regimen.

Reglan (metoclopramide) Dangers: Long term Reglan (metoclopramide) use can result in a permanent parkinson's like disorders, or tardive dyskinesia. This can develop after a fairly short period of a couple of months or less of regular use. It is meant to be used sparingly, and with oversight. A list of the potential side effects can be found here: http://www.rxlist.com/reglan-side-effects-drug-center.htm