My sister has had long term depression and was prescribed bupripion and prozac, but still wasnt working that great. she stopped prozac and started st johns wort but had problems with soreness in her breast (she has had a hysterectomy). she loved the st jo

Try alternate: buproprion and prozac are both class of drugs that either increase norepinephrine and serotonin respectively in the brain, under the assumption that increasing the amount of either would help depression. This doesn't work for everyone. Some do better with a class of drug known as atypical antipsychotics such as abliify, seroquel, (quetiapine) risperdal. I found them effective for non responders.