Is alcohol okay with 25 mg of zoloft (sertraline) once a day at night along with 5 mg of lotensin for high bp?

Can't say online: Best bet is to ask the physician who is prescribing these meds for you. Zoloft (sertraline) is an antidepressant / anti-anxiety drug. Alcohol is a depressant. So... Generally i would say that having 1-2 alcoholic beverages weekly is probably fine on this regimen, but having several drinks at once is a bad idea... In the end, check with your doctor about the specifics and about how much you intend to drink.